Pharmaceutical Intermediate O Methylisourea Hemisulfate Methylisourea Hemisulfate 98 Percent 52328 05 9

O-Methylisourea hemisulfate (CAS 52328-05-9), supplied as the hemisulfate salt for enhanced stability and ease of handling, is a high-purity guanidine derivative that functions as a versatile methylating agent and critical building block in heterocyclic synthesis. This white crystalline powder with a minimum assay of 98% is widely employed in pharmaceutical and agrochemical research for introducing methyl groups onto oxygen atoms and constructing nitrogen-containing ring systems.

• High Purity Salt Form: Minimum 98% assay ensures minimal side reactions and highly reproducible yields, with excellent solid-state stability
• Readily Soluble Crystalline Solid: White to off-white powder that dissolves easily in water, alcohols, and polar organic solvents
• Clear Chemical Traceability: Supplied with CAS 52328-05-9 for precise procurement and regulatory documentation
• Consistent Industrial Supply: Manufactured under controlled conditions for batch-to-batch uniformity from gram to kilogram quantities

O-Methylisourea hemisulfate serves as a selective methylating agent, particularly effective for O-methylation of carboxylic acids, phenols, and hydroxyl groups under mild conditions. It offers a less hazardous alternative to dimethyl sulfate in synthetic sequences.

As a heterocycle building block, the O-methylisourea moiety reacts with 1,3-dicarbonyl compounds, β-ketoesters, and α,β-unsaturated ketones to form pyrimidine, imidazole, and triazine rings. These scaffolds are essential in pharmaceutical agents including antiviral, antihypertensive, and anticancer drugs, as well as agrochemicals.

Additional applications include synthesis of creatine and its derivatives, and preparation of guanidine-based catalysts, ion-exchange resins, and specialty polymers.

• Superior Synthesis Efficiency: 98% purity grade translates to higher isolated yields and fewer purification cycles, reducing production costs
• Mild and Selective Reactivity: Controlled methylation profile minimizes hazardous waste and aligns with green chemistry principles
• Rigorous Quality Assurance: Each batch analyzed by titration and melting point determination with Certificate of Analysis
• Professional Packaging: Moisture-resistant fiber drums with inner polyethylene liners protect product during transit and storage
• Global Logistics Support: Complete documentation including MSDS, COA, and commercial invoice with reliable international shipping